Peptide Anchor for Folate-Targeted Liposomal Delivery

A novel peptide-grafted liposomal delivery system targeted to macrophages.

The interaction of chemotactic peptide (e.g., fMet-Leu-Phe)-grafted liposomes with macrophages is noted to be rapid and specific. At a grafted peptide concentration of 100 nmol, internalization of the peptide-grafted liposomes by the macrophages is found to reach equilibrium in 30 min. The peptide alone and the peptide-grafted empty liposomes are found to show moderate antileishmanial activity ...

Folate receptor-targeted anti-cancer agent delivery

Multifunctional targeted liposomal drug delivery for efficient glioblastoma treatment

Glioblastoma multiforme (GBM) has been considered to be the most malignant brain tumors. Due to the existence of various barriers including the blood-brain barrier (BBB) and blood-brain tumor barrier (BBTB) greatly hinder the accumulation and deep penetration of chemotherapeutics, the treatment of glioma remains to be the most challenging task in clinic. In order to circumvent these hurdles, we...

Surface Engineering of Liposomal Formulations for Targeted Drug Delivery

Liposomes, basically including lecithin and cholesterol, are classic nanovesicles to treat some diseases clinically. As the first FDA approved nanomedicine, Doxil® (Doxorubicin HCl Liposome Injection) is a successful formulation to inhibit the development of some cancer and improve the life time of the patients after tumor surgery [1]. However, the non-specific accumulation of liposomes in Reti...

Orally administered liposomal formulations for colon targeted drug delivery

Colon targeted drug delivery is an active area of research for diseases affecting the colon, as it shows promise in improving the efficacy of therapeutics and reducing systemic toxicity. Improved oral drug delivery design has unequivocally improved the bioavailability of drugs to the colon. The oral route of administration is the most common method of drug delivery. It is the preferred route of...